New research suggests co-administration with chemotherapy drugs most effective strategy
Researchers from Case Western Reserve University School of Medicine in collaboration with researchers from Dartmouth Geisel School of Medicine and RWTH Aachen University (Germany) have adapted virus particles that normally infect potatoes to serve as cancer drug-delivery devices for mice.
And in a recent article published in Nano Letters, the team showed injecting the virus particles alongside chemotherapy drugs, instead of packing the drugs inside, may provide an even more potent benefit.
The researchers discovered injecting potato virus particles into melanoma tumor sites activates an anti-tumor immune system response. In addition, injecting the nanoscale plant virus particles simultaneously with a chemotherapy drug—doxorubicin—into tumor sites further helps halt tumor progression in mice. But surprisingly, when the researchers created and injected combination nanoparticles, where the chemo drug is physically attached to the virus particles, there was not a significant added benefit.
The results are the first to show that “vaccinating” mice with potato virus nanoparticles at a cancer site can generate an anti-tumor response. But the results also suggest more complex nanoparticles may not correspond to added therapeutic benefit.
“It’s attractive to want to create multifunctional nanoparticles that can ‘do it all,’” said Nicole F. Steinmetz, senior author on the study, the George J. Picha Professor in Biomaterials, member of the Case Comprehensive Cancer Center and director of the Center for Bio-Nanotechnology at Case Western Reserve School of Medicine. “But this study shows significant therapeutic efficacy, including prolonging survival, requires a more step-wise approach. When the plant-based virus particles and the drugs were able to work on their own, we saw the greatest benefit.”
“While the nanomedicine field strives to design multifunctional nanoparticles that integrate several functions and therapeutic regimens into single nanoparticle, our data suggest a paradigm shift; some therapeutics may need to be administered separately to synergize and achieve most potent therapeutic outcome,” the authors wrote.
Steinmetz and her team will next investigate mechanisms behind the potato virus particles’ anti-tumor effects. She plans to test whether co-administering the nanoparticles with different chemotherapy drugs can delay, or slow the progression of other cancers.
“Dual-pronged therapeutic approaches may be our best defense against certain cancers,” said Steinmetz, also an associate professor of biomedical engineering, a joint department of the School of Medicine and Case School of Engineering. “And, virus-based nanoparticles like the ones in our study may be used to enhance efficacy of existing medications.”