Biomedical engineering’s Anant Madabhushi part of three teams receiving grants for cancer research

Anant Madabhushi, professor of biomedical engineering, and Lyndsay Harris, professor of medicine-hematology/oncology, were awarded a one-year, $50,000 grant titled, “Radiogenomic approach for predicting pathologic complete response in HER2+ breast cancers” as part of the Case Comprehensive Cancer Center’s developmental fund pilot grant program.

Co-investigators on the project include Hannah Gilmore, assistant professor of pathology, Vinay Varadhan, assistant professor of medicine, and Donna Plecha, associate professor of radiology.

Sanjay Gupta, the Carter Kissell Associate Professor and Research Director at the Case Western Reserve School of Medicine, and Madabhushi, who is also the director of the Center for Computational Imaging and Personalized Diagnostics, were awarded a three-year Department of Defense Idea grant for $594,000 for their project titled, “Integrating Molecular Biomarkers and Quantitative Histomorphometry for Prostate Cancer Prognosis.”

Gupta and Madabhushi will jointly develop algorithms and tools for combining molecular biomarkers and image-based features from pathology slides to better predict outcome for prostate cancer patients following radical prostatectomy. Greg MacLennan, professor of pathology is also part of the team.

Vamsidhar Velcheti, of Cleveland Clinic, and Madabhushi were awarded a one-year, $75,000 VeloSano Pilot Grant for their project titled, “Genomic Correlation of Computer-aided Radiographic and Histomorphometric Feature Extraction Based Models in Lung cancer and Novel Approach to Predicting Early Resistance to Targeted Therapy.”