Param Ramakrishnan, associate professor of pathology at the School of Medicine, recently gave a presentation at the Complex Carbohydrate Research Center at the University of Georgia.
Ramakrishnan’s presentation, titled “Dual Regulation of Transcription in T lymphocytes by NF-kappaB c-Rel O-GlcNAcylation,” was part of a unique American Society for Biochemistry and Molecular Biology meeting on the the posttranslational protein modification, O-GlcNAcylation.
The meeting drew experts in O-GlcNAc biology from around the world to discuss how O-GlcNAc and O-GlcNAc cycling enzymes modulate protein function in basic biological processes as well as in disease states, including diabetes, cancer, cardiovascular disease and neurological diseases.
Ramakrishnan’s lab is mainly focusing on O-GlcNAcylation in type 1 diabetes and leukemia at Case Western Reserve University and has contributed seminal findings in the field.