Parameswaran Ramakrishnan, professor of pathology and biochemistry, finds link between intestinal inflammation and gene expression in recent study

Parameswaran Ramakrishnan, assistant professor of pathology and biochemistry at Case Western Reserve University School of Medicine, recently co-authored an article, “Sam68 contributes to intestinal inflammation in experimental and human colitis,” investigating the role of an inflammation-related protein that may improve treatment outcomes for ulcerative colitis patients.

Ramakrishnan and colleagues’ study examined inflammatory gene expression in both human patients and mice induced with ulcerative colitis symptoms. Study results suggested deficiency of Sam68 was associated with reduced expression of inflammatory genes in mice, which may have important implications for treatment of ulcerative colitis in humans.

Ramakrishnan’s study was published by Cellular and Molecular Life Sciences in December 2021. Read the study online.