Computer screen showing DNA sequence with microscope and test tube in the background

CWRU researchers publish work on biosensors for marker of genetic disorders

A group of researchers from Case Western Reserve University and Taipei Medical University recently published “Application of bioconjugation chemistry on biosensor fabrication for detection of TAR-DNA binding protein 43” in Biosensors and Bioelectronics.

The group developed a single-use and cost-effective in vitro biosensor for the detection of TAR DNA-binding protein 43 (TDP-43), a biomarker of neurodegenerative disorders.

The researchers from CWRU were:

  • Yifan Dai, PhD candidate in the Department of Chemistry;
  • Chunlai Wang, PhD candidate in the Department of Chemistry;
  • Liang-Yuan Chiu, PhD candidate in the Department of Chemistry;
  • Kevin Abbasi, engineer with the Swagelok Center for Surface Analysis;
  • Blaton S. Tolbert, associate professor of chemistry;
  • Geneviève Sauvé, associate professor of chemistry; and
  • Chung-Chiun Liu, the Wallace R. Persons Professor of Sensor Technology & Control, Distinguished University Professor, professor of chemical engineering and director of the electronics design center.

Read “Application of bioconjugation chemistry on biosensor fabrication for detection of TAR-DNA binding protein 43” on Science Direct.