GENE 520: Human Computational Genomics and Epigenomics (4 credit hours) will be offered Fall 2025, Mondays and Wednesdays 1:00-2:50pm.
The purpose of the course is to acquaint students with current high-throughput techniques and computational pipelines to assay the human genome, epigenome, and transcriptome on a large scale. Topics will include next-generation sequencing pipelines (DNA variant calling, RNA sequencing, ATAC-seq, single-cell sequencing, spatial transcriptomics, etc.), as well as “best practices” for programming, software development, and distribution. It will be exclusively in-person, a combination of lecture, discussion, and hands-on sessions.
Although there are no formal prerequisites, the course will involve pipelines that make use of R, UNIX/Linux, and Python. Students will be introduced to these platforms early in the course, but additional resources will be provided for further help as needed.
Undergraduates, grad students, postdocs, staff, and faculty are welcome.
Please contact Thomas LaFramboise (TXL80@case.edu) with any questions.