Anant Madabhushi, associate professor in the Department of Biomedical Engineering, and investigators at the Case Comprehensive Cancer Center, including Lyndsay Harris, professor of medicine-hematology and oncology, and Hannah Gilmore, assistant professor of pathology, were awarded a one-year Clinical and Translational Science Collaborative and Case Coulter Translational Research Partnership grant for their proposal titled, “Computerized Histologic Image-based predictor of recurrence in breast cancers following treatment.”
Additional key personnel included Ajay Basavanhally, research associate in the Department of Biomedical Engineering.
The goal of this $50,000 pilot project is to develop a histologic image based predictor of treatment response in estrogen receptor positive breast cancers using advanced computer vision and machine learning tools to quantitatively extract patterns of tumor morphology, vascular density, proliferation index from immunohistochemistry and hematoxylin and eosin digitized histological images of biopsy specimens.