Anant Madabhushi, team earn patent for computer-assisted disease prognosis, digital pathology

Anant Madabushi in the classroom at CWRU

Anant Madabhushi, director of the Center of Computational Imaging and Personalized Diagnostics and professor of biomedical engineering, was awarded U.S. patent 9,183,350 for his invention titled “Quantitatively characterizing disease morphology with cell orientation entropy.”

The invention relates to the apparatus, methods and other embodiments associated with objectively predicting biochemical recurrence with cell orientation entropy. The technology describes the associate directional disorder of cells with risk of biochemical recurrence in a tissue. The invention could pave the way for developing computerized image-based predictors of disease aggressiveness and outcome from digitized tissue pathology alone.

Co-inventors include George Lee, research assistant professor of biomedical engineering; Sahirzeeshan Ali, graduate student in electrical engineering and computer science; and Rachel Sparks, research associate at University College London.