Researchers have article published in eLIFE

Researchers at Case Western Reserve University had an article titled “Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel” published in eLIFE.

The authors were:

  • Sandip Basak, a postdoctoral scholar in the Department of Physiology and Biophysics;
  • Nicolaus Schmandt (MED ‘16), a postdoctoral scholar at the University of Chicago;
  • Yvonne Gicheru, a PhD student in the Department of Physiology and Biophysics; and
  • Sudha Chakrapani, assistant professor of physiology and biophysics.

The researchers showed how docosahexaenoic acid affects bacterial pentameric ligand-gated ion channels in the same way as it affects human channels—by enhancing desensitization.

Read their article.